Tissue Engineering
"A cell is regarded as the true biological atom."
— George Henry Lewes
Tissue engineering enables the design and fabrication of novel biomaterials, such as scaffolds, implants, and matrices that mimic natural tissues' structural and functional properties and repair/replace damaged tissues and organs. My research involves developing and optimizing biomaterials (thin films, hydrogels, cryogels, etc.) for wound healing applications. I aim to not only create biomaterials but to fine-tune their properties to meet the specific requirements of wound healing, which includes ensuring biocompatibility, mechanical strength, and the ability to support cell adhesion and proliferation. Additionally, I explore various strategies for incorporating bioactive molecules into these biomaterials to enhance their regenerative potential. I am also interested in harnessing this technology to design meat alternatives (artificial/cultured meat) to help address growing concerns related to environmental sustainability and ethical food production.
Publications
1. Genipin cross-linked chitosan–PVA composite films: An investigation on the impact of cross-linking on accelerating wound healing
Reactive and Functional Polymers
DOI: 10.1016/j.reactfunctpolym.2022.105339
2. Curcumin-laden crosslinked chitosan–PVA films: The synergistic impact of genipin and curcumin on accelerating wound closure
JOM
DOI: 10.1007/s11837-023-06123-8
3. Artificial meat industry: Production methodology, challenges, and future
JOM
DOI: 10.1007/s11837-022-05316-x
Projects in Progress
1. A physicochemical and image based artificial intelligence approach in wound assessment using curcumin-laden surface-engineered Zn MOFs impregnated in bioresorbable nanofiber scaffolds
Correspondence: Goutam Thakur
2. In vivo, in-vitro and physiochemical studies of hydroxyapatite nanoparticle-enriched silk fibroin/PCL-based nanofibers for bone tissue engineering
Correspondence: Goutam Thakur
3. Fabrication of surface-engineered, curcumin-loaded cyclodextrin-based metal-organic frameworks as a topical spray to impede surgical site infections and promote wound healing
Correspondence: Goutam Thakur